CHRONECT HDX LC Columns |

Low-temperature HDX-MS can drive system pressure higher, limiting throughput, flexibility, and productive instrument time. CHRONECT™ HDX LC Columns are engineered specifically for chilled conditions, reducing pressure demands while maintaining chromatographic performance.

The result is a more robust, higher-capacity workflow that helps commercial, research, and core laboratories complete more samples, reduce avoidable interruptions, make better use of staff and instruments, and generate more data to support scientific progress.

The analytical column is often treated as a commodity — but in an HDX workflow, it directly shapes runtime, pressure, and data quality.

CHRONECT HDX LC Columns are purpose-built for the demands of chilled HDX-MS operation, giving laboratories a foundation to run faster, more flexible methods without compromising separation quality.

Advantages Include:

Substantially lower operating backpressure, even at 0°C
Greater freedom to optimize flow rates and gradients
Protects system components while maintaining chromatographic quality

The analytical column is often treated as a commodity — but in an HDX workflow, it directly shapes runtime, pressure, and data quality.

CHRONECT HDX LC Columns are purpose-built for the demands of low-temperature HDX-MS operation, giving laboratories a foundation to run faster, more flexible methods without compromising separation quality.

Advantages Include:

Substantially lower operating backpressure, even at 0°C
Greater freedom to optimize flow rates and gradients
Protects system components while maintaining chromatographic quality

CROs

Support reliable project delivery and maintain client confidence.

Increase sample throughput, reduce turnaround times, and minimize workflow disruptions.

Laboratory Managers

Optimize instrument utilization and staff resources.

Reduce pressure-related workflow interruptions and routine maintenance requirements.

Academic PIs

Maximize productive research time.

Generate more data using existing staff and instrumentation, while reducing time spent on routine oversight.

Core Facilities

core-facilities

Decrease sample backlog and expand user access.

Increase daily sample throughput per instrument without requiring immediate capital investment..

Built for modern HDX analysis

Pairing the CHRONECT™ HDX LC Column with HDExaminer™ PRO helps create a more streamlined path from separation through data analysis. HDExaminer PRO can significantly reduce the time required to process HDX-MS data, while the CHRONECT HDX LC Column supports robust, efficient chromatography upstream.

Together, they help you move from raw data to reliable, confident results faster—supporting greater productivity, a more integrated CHRONECT workflow, and more time for scientific interpretation and decision-making.

Built for modern HDX analysis

Pairing the CHRONECT™ HDX LC Column with HDExaminer™ PRO helps create a more streamlined path from separation through data analysis. HDExaminer PRO can significantly reduce the time required to process HDX-MS data, while the CHRONECT HDX LC Column supports robust, efficient chromatography upstream.

Together, they help you move from raw data to reliable, confident results faster—supporting greater productivity, a more integrated CHRONECT workflow, and more time for scientific interpretation and decision-making.

More capacity. Better confidence.

The benefits add up

Improved uptime and robustness

Lower backpressure reduces system stress and service interruptions so you can rely on your workflow.

More capacity from your system

Shorter run times mean more runs per day and better use of your MS instrument.

Better data for greater confidence

Run more replicates and conditions to strengthen your data and support better decisions.

increased-laboratory-productivity

Higher lab productivity greater efficieny

Use your scientist time where it matters most and support more projects.

Length	Identification	Part number
100 (mm)	1.0 (mm)	CHR-HD-LC-100.1
50 (mm)	1.0 (mm)	CHR-HD-LC-50.1
100 (mm)	0.3 (mm)	CHR-HD-LC-100.3
50 (mm)	0.3 (mm)	CHR-HD-LC-50.3
150 (mm)	0.15 (mm)	CHR-HD-LC-150.15
50 (mm)	0.15 (mm)	CHR-HD-LC-50.15

Evaluation Guide

A practical guide for evaluating CHRONECT HDX LC Column performance in your existing HDX-MS workflow.

Manual

The complete manual for installing, implementing, optimizing, and routinely using CHRONECT HDX LC Columns in HDX-MS workflows.

Specification Sheet

CHRONECT HDX LC Column benefits, format options, and representative performance for modern HDX-MS workflows.

Infographic

Overview of the CHRONECT HDX LC Column benefits. Lower backpressure, shorter run times, increased capacity, and improved workflow confidence.

HDX Workflow Brochure

An overview of the complete CHRONECT HDX workflow, combining automation, workflow-optimized consumables, HDExaminer PRO software, training, and support.

hdx-workflow-solution