HDX Projects Completed in Hours ...Not Weeks
Confidently identify the binding site — FAST
The NEW HDExaminer PRO, part of the CHRONECT Studio platform, is an advanced software solution for HDX-MS data analysis. Built to eliminate manual processing and improve accuracy, it delivers fast, high-confidence results that accelerate your ability to identify epitopes, map binding sites, and study protein dynamics.
Designed for researchers in pharma, academia, and contract services, HDExaminer PRO transforms complex HDX workflows into an intuitive, fully automated process - helping you move your research and discovery forward faster. Formerly known as AutoHX, the software was renamed following its acquisition by Trajan in 2024.
Accelerating discovery at the world’s leading labs
Precision & Compliance Without the Manual Burden
Ensuring the safety of food products is your top priority. Mineral oil hydrocarbons present serious health risks and are tightly regulated. Automated CHRONECT MOSH/MOAH workstations by Trajan enable you to…Trusted by scientists who need speed, accuracy, and confidence
Traditional HDX-MS data analysis can be slow, subjective, and error-prone. HDExaminer PRO changes the game with:
Analyze typical files in 2–5 minutes – even with 1,000 peptides.
Effortlessly handle multi-timepoint, multi-state experiments.
Verify peptides using data-independent acquisition (DIA) data – not just static lists.
10x more data points per peptide vs. conventional HDX software.
Guided workflow makes complex HDX project setup easy.
Heatmaps, volcano plots, peptide maps (exportable to PyMOL, Chimera), and kinetics plots.
Quick assessment of HDX data quality and project results.
Export full result bundles including spreadsheets, images, and publication-ready plots
Purpose-built for your protein characterization needs
Accurate
Unmatched precision with verified peptides and redundant measurements.
Fast
Process large datasets in minutes, not weeks. Accelerating drug discovery, publications, and HDX-MS services.
Smart
Transform raw mass spectrometry data into actionable insights without the need for manual intervention.
“Integrating the CHRONECT MOSH/MOAH workstation into our lab has been a game-changer. We’re able to handle more samples in less time, and the consistency across runs is remarkable. It’s become an essential part of our workflow for detecting mineral oil contaminants with confidence.”
“Integrating the CHRONECT MOSH/MOAH workstation into our lab has been a game-changer. We’re able to handle more samples in less time, and the consistency across runs is remarkable. It’s become an essential part of our workflow for detecting mineral oil contaminants with confidence.”
“Integrating the CHRONECT MOSH/MOAH workstation into our lab has been a game-changer. We’re able to handle more samples in less time, and the consistency across runs is remarkable. It’s become an essential part of our workflow for detecting mineral oil contaminants with confidence.”
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HDExaminer™ PRO - A paradigm shift in rapid and accurate processing of HDX experiments.
Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology.
Nat Commun 15, 2200 (2024).
Examining Instrumental Factors Influencing the Performance of Data-Independent Acquisition Methods in Hydrogen/Deuterium Exchange Mass Spectrometry.
Analytical Chemistry 97, 8011–8020 (2025)
FAQs
CHRONECT Studio is a comprehensive structural biology software platform that hosts a suite of specialized applications, each designed for different purposes. HDExaminer PRO is one of these applications, purpose-built for HDX-MS data analysis.
Yes – we encourage current HDExaminer users to explore HDExaminer PRO. Simply contact us, and our team will provide a demo license along with guidance to help you get started.
HDExaminer PRO is a next-generation HDX-MS analysis solution that introduces significant advancements over the original HDExaminer. While HDExaminer offers semi-automated analysis based on a static peptide list, HDExaminer PRO leverages an additional dimension of data that conventional tools cannot fully exploit. This enables two key capabilities:
- Peptide Identification Validation: HDExaminer PRO incorporates an automated authentication step that directly validates peptide identities during analysis — improving confidence and reducing reliance on external peptide lists.
- Enhanced Accuracy Through Redundancy: The software generates multiple layers of corroborative measurements for each peptide, improving precision, reducing false positives, and delivering higher-confidence results.
These innovations allow HDExaminer PRO to deliver superior speed, accuracy, and reliability – setting a new standard for automated HDX-MS data analysis.
Yes, we offer special pricing for academic institutions. Please contact our team to learn more about available discounts and how to qualify.
Yes, we provide virtual demos to showcase the software’s capabilities, along with demo licenses so you can try HDExaminer PRO firsthand. Contact our team to schedule your demo and receive access.
HDExaminer PRO is offered as an annual subscription license, which includes software updates and standard support throughout the subscription period.
Discuss pricing and get your FREE demo
HDExaminer PRO is available via annual subscription for both commercial and academic users. Discounts are available for early adopters, multi-seat licenses, and hardware bundles. Ready to see how HDExaminer PRO can accelerate your HDX-MS research? Contact us today to discuss pricing and start your free demo.
Maximize your workstation performance with expert training and ongoing support
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